Vardenafil hydrochloride CAS 224785-91-5 . The main ingredient of this product is vardenafil hydrochloride. It is a white or almost white crystalline powder, odorless, astringent and bitter in taste, soluble in water and ethanol. After removing the film coating, it appears white. Adapt to the treatment of male erectile dysfunction (ED).

Chinese name: Valdenafil Hydrochloride

Foreign name: Vardenafil hydrochloride

Chemical formula: C23H33ClN6O4S

CAS: 224785-91-5

Molecular weight: 525.06

Melting point: 214-216 ° C

Pharmacological properties

Vardenafil enhances the natural response to sexual stimulation by inhibiting the degradation of cGMP by phosphodiesterase type 5 (PDE5) in the human penile sponge, increasing the release of endogenous nitric oxide in the sponge under sexual stimulation.

Vardenafil is a highly selective PDE-5 enzyme inhibitor that primarily exerts therapeutic effects by specifically inhibiting the activity of PDE-5 enzymes, leading to penile erection. Compared with similar products, this drug has the characteristics of fast onset, sustained and reliable efficacy, high erection quality, and good safety. After taking vardenafil, clinical reports show that 35% of people take effect within 15 minutes, with an effective rate of 81% within 30-1 hours, and a half-life equivalent to sildenafil. The advantages and disadvantages of vardenafil compared to sildenafil and sildenafil (Tadanafil) in terms of PDE-5 inhibitors: the IC50 of the PDE-5 inhibitor Tadanafil is 0.9nM~6.7nM, while the IC50 of vardenafil is 0.1Nm~0.7nM. Obviously, the inhibitory ability of vardenafil on PDE-5 is five times that of sildenafil. The selective binding ability of PDE-5 inhibitors to other PDE isoenzymes (such as PDE1-4, PDE7-10, and PDE-5) is not significantly different, but it does exist for PDE-6.

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